USE OF GK-1 PEPTIDE EXPRESSED ON M13 FILAMENTOUS PHAGE AS PHARMACEUTICAL INGREDIENT TO ENHANCE THE EFFICIENCY OF THE IMMUNE RESPONSE INDUCED BY VACCINE OR PATHOGEN ANTIGENS
Edda Lydia Sciutto Conde,Gladis del Carmen Fragoso Gonzalez,René Alvaro Segura Velázquez,Jacquelynne Brenda Cervantes Torres,Karen Manucharyan,Abel Blanca Cabrera,Rutilia Marisela Hernandez Gonzalez
申请号：
US14234983
公开号：
US20140302085A1
申请日:
2012.07.28
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention is directed to the use of FGK-1 immunopotentiator, composed by the peptide named GK-1, characterized by the sequence G-Y-Y-Y-P-S-D-P-N-T-F-Y-A-P-P-Y-S-A and linked to the pVIII surface protein of M13 filamentous phage, to prepare pharmaceutical products potentiating the protective immune response of vaccine antigens when used by itself or conjointly with these antigens administered either intranasally, subcutaneously, or intramuscularly, yielding an increase in the level of specific antibodies against vaccine antigens in serum and in bronchoalveolar lavages.
