Eugene C. Yi;Brian A. Fox;Wenfeng Xu;Cameron S. Brandt;Zeren Gao;Pallavur V. Sivakumar;Jacob J. Kennedy
发明人:
Cameron S. Brandt,Jacob J. Kennedy,Wenfeng Xu,Eugene C. Yi,Brian A. Fox,Zeren Gao,Pallavur V. Sivakumar
申请号：
US12943256
公开号：
US08969518B2
申请日:
2010.11.10
申请国别(地区):
US
年份:
2015
代理人:
摘要：
Disclosed is a newly identified B7 family member, zB7H6, which functions as a counter-receptor for the NK cell triggering receptor, NKp30. Methods and compositions for modulating NKp30-mediated NK cell activity based on the interaction of zB7H6 with NKp30, as well as related screening methods, are also disclosed. Further disclosed are anti-zB7H6 antibodies as well as antibody-drug conjugates comprising an anti-zB7H6 antibody conjugated to a therapeutic agent, including methods for using such antibodies and antibody-drug conjugates to exert therapeutic effects against zB7H6-expressing cells.
