A process has been found which increases the efficiency and effectiveness of introducing antimicrobial compounds into complex biofilm matrices through the use of liposome carriers, thereby removing the biofouling in industrial water bearing systems, including piping, heat exchanges, condensers, filtration systems and fluid storage tanks. According to one embodiment of the invention, antimicrobial compound containing liposomes are added to water systems prone to biofouling and biofilm formation. The liposomes, being similar in composition to microbial membranes or cells, are readily incorporated into the existing biofilm. Once the antimicrobial compound containing liposomes become entrained with the biofilm matrix, the decomposition or programmed disintegration of the liposome proceeds. Thereafter, the biocidal aqueous core is released to react directly with the biofilm encased microorganisms. Upon the death of the organisms, the polysaccharide/protein matrix decomposes and thereby results in reduced fouling of the water bearing system, resulting in increased heat transfer, increased flux, less deposit of colloidal and particulate solids and dissolved organics on the surface of the microfiltration membrane, thereby reducing the frequency and duration of the membrane cleaning and ultimate replacement.Linvention concerne un procédé qui a été découvert comme augmentant lefficience et lefficacité de lintroduction de composés antimicrobiens dans des matrices complexes de biofilm par lutilisation de vecteurs liposomaux, ce qui élimine ainsi lencrassement biologique dans des systèmes industriels contenant de leau, comprenant des tuyaux, des échangeurs de chaleur, des condenseurs, des systèmes de filtration et des cuves de stockage de fluides. Selon un mode de réalisation de linvention, des liposomes contenant un composé antimicrobien sont ajoutés à des systèmes aqueux enclins à un encrassement biologique et à une formation de biofilm. Les liposomes, de par leur similitude d