A pharmaceutical composition for inducing or accelerating a healing process of a damaged skin or skin wound, the pharmaceutical composition comprises, as a n active ingredient, a therapeutically effective amount of insulin and at leas t one additional agent acting in synergy with said insulin, and a pharmaceutically acceptable carrier being designed for topical application o f the pharmaceutical composition. A method of inducing or accelerating a heali ng process of a damaged skin or skin wound, the method comprises administering to the damaged skin or skin wound a therapeutically effective amount of insulin and at least one additional agent acting in synergy with said insulin to induce or accelerate the healing process of the damaged skin or the skin wound.