THE UNITED STATES OF AMERICA; as represented by the Secretary; Department of Health and Human Services
发明人:
Dennis M. Klinman,Hiroyasu Ito
申请号：
US14397156
公开号：
US10076535B2
申请日:
2013.03.29
申请国别(地区):
US
年份:
2018
代理人:
摘要：
Pharmaceutical compositions are provided that include an antibiotics, but that include ingredients that counteract the effect of that antibiotic on wound healing, without altering the bactericidal properties of the antibiotic. These pharmaceutical compositions include an effective amount of 1) an imidazoquinoline having toll-like receptor 7 (TLR7) ligand activity, 2) an immunostimulatory K-type CpG oligodeoxynucleotide (ODN) comprising an unmethylated CpG motif, 3) an antibiotic, and 4) a surfactant, wherein the composition is formulated for topical administration. Methods for accelerating wound healing are also provided. These methods include topically administering the disclosed compositions. The wound can be in the skin or in the eye.
