Methods, systems, and devices for applying targeted force to a radial access puncture site to aid in arresting bleeding at the puncture site. Such a device may include a cuff (e.g., band) for placement over a wrist of a patient, and an inflatable balloon attached to the cuff and disposed over the puncture site during use, such that the inflatable balloon applies pressure to the site during use. The device includes targeting indicia disposed on (i) the inflatable balloon, and/or (ii) an optional rigid or semi-rigid member (e.g., as a backing layer for the balloon). The targeting indicia identifies that portion of the balloon to be positioned on the puncture site so that the inflated balloon applies pressure to the site during use. An associated system may include a cuff device, and a fluid source from which an inflation fluid may be delivered into the inflatable balloon during use.
