AUSTRALIAN NUCLEAR SCIENCE AND TECHNOLOGY ORGANISATION
发明人:
BARBE, CHRISTOPHE, JEAN, ALEXANDRE,FINNIE, KIM, SUZANNE
申请号：
NZ59518509
公开号：
NZ595185A
申请日:
2009.12.22
申请国别(地区):
NZ
年份:
2012
代理人:
摘要：
A method is described for delivering a species to a liquid, whereby porous particles are exposed to a condition such that the species is rapidly released into the liquid. Each of the porous particles comprises an agglomeration of primary particles so that outer surfaces of said primary particles define pores of said porous particles. The primary particles comprise silica and the species is disposed in the pores of the porous particles. The porous particles may be dispersed in a diluent. The diluent may be the liquid to which the species is to be delivered. It may be some other diluent. It may be miscible with the liquid to which the species is to be delivered. The exposing may be in the presence of the liquid. In many embodiments either the porous particles are provided in the liquid or the step of exposing comprises exposing the porous particles to the liquid The species may be a biological species. It may be, or may comprise, a protein, a peptide, an oligopeptide, a synthetic polypeptide, a saccharide, a polysaccharide, a glycoprotein, an enzyme, DNA, RNA, a DNA fragment or a mixture of any two or more of these. It may be, or may comprise, some other macromolecular species. It may be, or may comprise, a polymer, e.g. a polymeric dye. It may be, or may comprise, a particulate species. It may be, or may comprise, cells or viral particles. The species may be any suitable species that is sufficiently large (e.g. has sufficiently large diameter) to remain encapsulated by the porous particles and not be released to a substantial degree until the porous particles are exposed to the condition leading to rapid release of said species. The condition may be such that the silica of the primary particles at least partially dissolves or hydrolyses so as to rapidly release the species. It may be such that bridges joining the primary particles at least partially dissolve or hydrolyse. Said dissolution or hydrolysis may result in at least partial disintegration or de-aggregation o
