PROBLEM TO BE SOLVED: To elucidate the mechanism of the onset of leukoplakia in the skin affected by rhododenol, and to provide a medicine using the mechanism.SOLUTION: We found out that by using rhododenol, inducing the immune response specific to a self-tyrosinase peptide is possible, and thereby treating melanoma is possible. We also found out that in various tumor antigens, identifying a compound that produces a cryptic peptide and induces antitumor immune response using conjugation to tumor antigens as an indication to use as tumor antigens and the like is possible.SELECTED DRAWING: NoneCOPYRIGHT: (C)2016,JPO&INPIT