The present invention relates to the use of at least one glucose derivative, halogenated in the 6-position, for implementing a method for determining the insulin resistance in a mammal, in particular a human, by measuring - the variation in the amount (as a function of time) of the abovementioned derivative, in muscle cells, for a given period Δt, after administration of the abovementioned derivative, and - the variation in the amount (as a function of time) of the abovementioned derivative, in the abovementioned muscle cells, for a period substantially equal to the abovementioned period Δt, after administration of the abovementioned derivative, preceded by an administration of insulin.