For region of interest (ROI) placement in quantitative ultrasound imaging with an ultrasound scanner, the ROI is automatically placed using anatomy detection specific to the quantification, signal processing for clutter, attenuation, or noise, and/or identification of regions of fluid. For quantification, multiple ROIs may be positioned automatically. The automatic placement may improve consistency of measures over time and between sonographers and may provide for better image quality with less influence from undesired signals. As a result, diagnosis and/or treatment may be improved.
