The present invention relates to a combination comprising a substance with inhibiting effect on the ileal bile acid transport system (I BAT) and at least one other active substance selected from an IBAT inhibitor； an enteroendocrine peptide or enhancer thereof； a dipeptidyl peptidase-IV inhibitor； a biguanidine； an incretin mimetic； a thiazolidinone； a PPAR agonist； a HMG Co-A reductase inhibitor； a bile acid binder； and a TGR5 receptor modulator； wherein the IBAT inhibitor compound and the at least one other active substance are adminstered simultaneously, sequentially or separately.
