RECEPTEURS CHIMERIQUES ACTIVATEURS ET LEURS UTILISATIONS DANS UNE IMMUNOTHERAPIE PAR CELLULES TUEUSES NATURELLES

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专利权人:

NATIONAL UNIVERSITY OF SINGAPORE

发明人:

SEOW, SEE VOON,CAMPANA, DARIO

申请号：

CA3089170

公开号：

CA3089170A1

申请日:

2019.02.07

申请国别(地区):

CA

年份:

2019

代理人:

摘要：

Current invention relates to a polynucleotide encoding activating chimeric receptors comprising engineered Natural Killer Group 2 member C (NKG2C) having enhanced affinity for HLA class I histocompatibility antigen alpha chain E (HLA-E)/peptide complex or an extracellular receptor domain of NKG2A coupled to an effector domain. It also relates to NK cells expressing such constructs and the use of these NK cells to induce cytotoxicity. It further exemplifies that the NK cells expressing polynucleotide encoding NKG2C (SIIS)/CD94/DAP12 or NKG2C/CD94/4-1 BB/CD3z showed enhanced NK cytotoxicity against cancer cells.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/