НОВАРТИС АГ (CH);ДЗЕ ТРАСТИЗ ОФ ДЗЕ ЮНИВЕРСИТИ ОФ ПЕНСИЛЬВАНИЯ (US)
发明人:
ДЖИЛЛ, Саар (US),РУЕЛЛА, Марко (US),КЛИЧИНСКИ, Майкл (US)
申请号：
RU2019105693
公开号：
RU2019105693A
申请日:
2017.08.01
申请国别(地区):
RU
年份:
2020
代理人:
摘要：
The invention provides compositions and methods for treating diseases associated with expression of an antigen, e.g., a solid tumor antigen or antigen expressed on a tumor associated with TAMs and/or MDSCs, by administering a recombinant T cell comprising a CAR binding to said antigen, as described herein, in combination with an inhibitor of a pro-M2 macrophage molecule, e.g., described herein. The invention also provides kits and compositions described herein.
