That includes: a method to prepare triazolopiridina substituted compounds of the General formula (i) as described and defined in the present. Intermediates useful for preparing such Compounds, compounds that inhibit the guinasa MPS - 1.Preferred compounds are (2R) - 2 - (4-fluorophenyl) - N - [4 - (2 - {[2 - methoxy - 4 - (methylsulfonyl) phenyl] amino} [1,2,4] triazolo [1, 5-a] pyridin-3 (IL - 6) phenyl] propanamide, (2R) - N - [4 - (2 - {[2 - ethoxy - 4 - (methylsulfonyl) phenyl] amino} [1, 2, 4] triazolo [1,5-a] pyridin-3 (IL - 6) phenyl] - 2 - (4-fluorophenyl) propanamide among othersQue comprende: un metodo para preparar compuestos de triazolopiridina sustituida de la formula general (I) como se describen y definen en la presente. Compuestos intermediarios utiles para preparar dichos compuestos, que inhiben la guinasa Mps-1. Son compuestos preferidos: (2R)-2-(4-fluorofenil)-N-[4-(2-{[2-metoxi-4-(metilsulfonil) fenil] amino}[1,2,4] triazolo[15-a]piridin-6-il)fenil] propanamida, (2R)-N-[4-(2-{[2-etoxi-4-(metilsulfonil) fenil]amino}[1, 2, 4] triazolo[1,5-a]piridin- 6-il) fenil]-2-( 4-fluorofenil) propanamida entre otros
