LISE GIEHM,JOLANTA SKARBALIENE,JESPER MOSOLFF MATHIESEN,OLIVER DEMMER,RASMUS JUST
申请号：
ARP140103476
公开号：
AR097701A1
申请日:
2014.09.18
申请国别(地区):
AR
年份:
2016
代理人:
摘要：
Claim 1: A compound having the formula (1): R¹-Z-R² (1) wherein R¹ is hydrogen, C₁₋₄ acyl,b. Benzoic acid or acrylic acid c83321c 83318324；Or the extended half life of M. in this half life, M can be compared with Z through another part of a connection. Is it Wu or NHR,2. R3 is hydrogen or c833218331-83323；2；X1 was selected from Trp, Lys and Arg groups； X3 from Gly, ASN, Glu and pro groups； x1 830404 from Gln, ASP and Glu groups； x1 830808 from ASP and Glu groups； x1 8310e Leu absent； x1 8311es his absent； x1 831222 from this group； a. Consisting of his and Arg, or absent； x1 8313 selected from the group, including present and present or absent； x2 83044 is present or present absent； x2 1 selected from the group consisting of the registrar system administrator, present or present absent； x2 selected from the group consisting of the registrar system administrator, present or present absent；X²³ is selected from the group consisting of Phe and D-Phe, or is absent； X²⁴ is Gly (Me) or is absent； X²⁵ is Ala or is absent； X²⁶ is Ile (Me) or is absent； X²⁷ is Leu or is absent； X²⁸ is selected from the group consisting of Ser, Ser (Me),D-Ser and D-Ser (me)(o) X2 8313 was selected from survival and survival group；o est ausente X es Thr o est ausente X se selecciona del grupo que consiste en Asp Glu y Asn X se selecciona del grupo que consiste en Asp Glu y Asn y X se selecciona del grupo que consiste en Tyr Tyr (Me)Pro, Hyp, APR, aze, Pip, PHP, PHP, PHP, PHP and BEP； the parentheses (...) associated with two kinds of ethylene oxide (C, Cys) in the second and seventh sequence positions indicate that there are intramolecular desulfurization bridges between the two residues of ethylene oxide； there may not be more than three positions, 1. The conditions are: (I) if two positions are absent, they are adjacent to each other, or one position is absent；(II) if three positions are absent, two adjacent and the other x2 832099；or one of its pharmaceutically acceptable salts or solvates.
