NOUVEAU DERIVE D'INDENE, SON PROCEDE DE PREPARATION, ET COMPOSITION PHARMACEUTIQUE POUR LA PREVENTION OU LE TRAITEMENT DE MALADIES RETINIENNES EN CONTENANT COMME PRINCIPE ACTIF
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY(IAC);충남대학교산학협력단
发明人:
KIM, Eunhee,김은희,JOO, Choun-Ki,주천기,YOO, Sung-Eun,유성은,KANG, Nam Sook,강남숙,KOO, Tae-Sung,구태성,PARK, Min-Young,박민영,KIM, Young-Hoon,김영훈,BAE, Hyun-Ju,배현주,KIM, Jin-Woo,김진우,IN, Tae-Kyu,인태규
申请号：
KRKR2015/007562
公开号：
WO2016/017980A1
申请日:
2015.07.21
申请国别(地区):
KR
年份:
2016
代理人:
摘要：
The present invention relates to a novel indene derivative, a preparation method for same, and a pharmaceutical composition, for preventing or treating retinal diseases, containing same as an active ingredient. A novel indene derivative, an optical isomer of same, or pharmaceutically acceptable salts of same, according to the present invention, has excellent inhibitory efficiency of receptor-interacting serine/threonine-protein kinase 1 (RIPK1). Therefore, a composition containing same as an active ingredient can be utilized as a pharmaceutical composition for preventing or treating retinal diseases such as retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), Stargardts disease, Usher syndrome, choroideremia, rod-cone or cone-rod dystrophy, ciliopathy, mitochondrial disorders, progressive retinal atrophy, degenerative retinal diseases, age-related macular degeneration (AMD), wet AMD, dry AMD, geographical atrophy, inherited or acquired macular degeneration, retinal photoreceptor diseases, retinal pigment epithelial diseases, diabetic retinopathy, cystic macular edema, uveitis, retinal detachment, traumatic retinal injury, iatrogenic retinal injury, macular holes, macular capillarectasia, ganglion cell diseases, optic nerve diseases, glaucoma, optic neuropathy, ischemic retinal diseases, retinopathy of prematurity, occlusion of retinal vessels, inherited macroaneurysm, retinal vascular diseases, ophthalmic vascular diseases, glaucomatous retinal neurodegeneration, ischemic optic neuropathy and the like.La présente invention concerne un nouveau dérivé d'indène； son procédé de préparation； et une composition pharmaceutique, pour la prévention ou le traitement des maladies rétiniennes en contenant comme principe actif. Un nouveau dérivé d'indène, un isomère optique de celui-ci, ou des sels pharmaceutiquement acceptables de celui-ci, selon la présente invention, possède une excellente efficacité inhibitrice du récepteur interagissant avec la protéine kinase sérin
