David I. Stirling;Laure A. Moutouh-De Parseval;Kyle W. H. Chan;Robert J. Hariri
发明人:
Robert J. Hariri,David I. Stirling,Laure A. Moutouh-De Parseval,Kyle W. H. Chan
申请号：
US12396397
公开号：
US08889411B2
申请日:
2009.03.02
申请国别(地区):
US
年份:
2014
代理人:
摘要：
The present invention relates to methods of modulating mammalian stem cell and progenitor cell differentiation. The methods of the invention can be employed to regulate and control the differentiation and maturation of mammalian, particularly human stem cells along specific cell and tissue lineages. The methods of the invention relate to the use of certain small organic molecules to modulate the differentiation of stem or progenitor cell populations along specific cell and tissue lineages, and in particular, to the differentiation of embryonic-like stem cells originating from a postpartum placenta or for the differentiation of early progenitor cells to a granulocytic lineage. Finally, the invention relates to the use of such differentiated stem or progenitor cells in transplantation and other medical treatments.
