A portable ultrasound cart includes a support structure configured to releasably secure a portable ultrasound device. The support structure includes a wall and a planar surface which define a recess structured to receive a portion of the portable ultrasound device, a first male engagement feature positioned to engage with a first female engagement feature of the portable ultrasound device and a second male engagement feature positioned to engage with a second female engagement feature of the portable ultrasound device. The portable ultrasound cart also includes a tilt system positioned to adjust a tilt angle of the support structure relative to a remainder of the portable ultrasound cart, and a release lever linked to the second male engagement feature such that when the release lever is actuated, the second male engagement feature of the portable ultrasound cart disengages from the second female engagement feature of the portable ultrasound device.