JEAN RANCOURT,TIMOTHY A. STAMMERS,YOULA S. TSANTRIZOS,CHRISTIAN BROCHU,MARTIN POIRIER,PIERRE BEAULIEU,BOUNKHAM THAVONEKHAM,CATHERINE CHABOT
申请号：
ARP130103893
公开号：
AR093144A2
申请日:
2013.10.25
申请国别(地区):
AR
年份:
2015
代理人:
摘要：
Claim 1: a compound represented by formula (1),or an enantiomer, diasteromer or tautomer thereof, including a salt or ester thereof, in which: either A or B is N and the other of B or A is C, where - - - - between two C atoms represents a double bond and - - - - between an atom C and an atom of N represents a simple bond； R¹ is H or C₁₋₆ alkyl；R² is selected from halogen, cyano, C₁₋₆ alkyl,C₂₋₆ alkenyl,1. C83228331 asphalt；C₃₋₇ cycloalkyl,Arilo and het； these arilo and het can be replaced by R2；In each case, R2 is one, two, or three independent alternatives - Oh, CN, n (RN 2) Rn,halogen, C₁₋₆ alkyl,C₁₋₆ alkoxy,1. C833218331-832626-tio, het y-co-n (RN Square) RN1；wherein said C₁₋₆ alkyl,C₁₋₆ alkoxy and C₁₋₆-thio alkyl are optionally substituted in each case with one, two or three halogen atoms； R³ is C₅₋₆ cycloalkyl；optionally substituted with one to four halogen atoms； R⁴ and R⁷ are independently selected in each case of H, C₁₋₆ alkyl,C₁₋₆ alkoxy,alquil C₁₋₆-tio, -NH₂,-NH-alquilo OLD,-NH (C₁₋₆ alkyl) hal and halogen； one of R⁵ and R⁶ is selected from -COOH, -CO-N (RN²) RN¹,Arilo, het and alquenilo c83231；a. Any heterocycle formed between arilo, het, alquenilo c832283331 and RN1 or RN2 and RN1 can be replaced by r8309； 83044；wherein R⁵⁰ is one, two or three substituents independently selected in each case of C₁₋₆ alkyl,-COOH -OH oxo -N (RN) RN-CO-N (RN²) RN¹ and halogen, wherein the C₁₋₆ alkyl is optionally substituted with aryl or N (RN²) RN¹；and the other of R⁵ and R⁶ is selected from H, C₁₋₆ alkyl,C₁₋₆ alkoxy,1. C832188331-832626-tio and n (RN Square) Rn；R⁸ is C₁₋₆ alkyl,C₃₋₇ cycloalkyl or C₃₋₇ cycloalkyl-C₁₋₆ alkyl；wherein said alkyl, cycloalkyl and cycloalkylalkyl are optionally substituted in each case with one, two or three substituents independently selected in each case from halogen, C₁₋₆ alkoxy and C₁₋₆-thio alkyl； R⁹ and R¹⁰ are independently selected in each case from C₁₋₆ alkyl；O r8313 and r83044 are linked with the carbon atoms to form c833238331；C₅₋₇ c
