ENZYCHEM LIFESCIENCES CORPORATION ;KOREA RESEARCH INSTITUTE OF BIO SCIENCE AND BIOTECHNOLOGY
发明人:
OH Sei-Ryang,AHN Kyung Seop,LEE Su Ui,SHIN In Sik,KWON Ok-Kyoung,KIM Seung Hyung,CHUN Chan Mi,LEE Tae-Suk,HAN Yong-Hae,SOHN Ki Young,KANG JongKoo,KIM Hye Kyung
申请号：
US201715857933
公开号：
US2018280336(A1)
申请日:
2017.12.29
申请国别(地区):
美国
年份:
2018
代理人:
摘要：
The present invention relates to a pharmaceutical composition containing a monoacetyldiacylglycerol compound as an active ingredient for preventing or treating chronic obstructive pulmonary diseases, and a functional health food composition for treating or preventing chronic obstructive pulmonary diseases. The monoacetyldiacylglycerol compound of the present invention inhibits the IL-4 expression in EL-4 cells and inhibits the infiltration of inflammatory cells into the bronchial tube in an animal model. In addition, the compounds of the present invention have an excellent effect of inhibiting the expression of CXCL-1, TNF-α, or MIP-2, thereby overcoming side effects of the currently used therapeutic agents for chronic obstructive pulmonary diseases, having no toxicity, and exhibiting a superior therapeutic effect, and thus can be useful as a composition for preventing, treating, and alleviating chronic obstructive pulmonary diseases.
