Dana-Farber Cancer Institute, Inc.;Yale University
发明人:
Nathanael Gray,Ting Xie,Sang Min Lim,Pasi A. Janne,Craig M. Crews
申请号：
US16179833
公开号：
USRE048175E1
申请日:
2018.11.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a kinase, such as Her3 protein kinase； L1 represents a linker； and RH represents a hydrophobic group. An example of a compound of Formula (I) is a compound of Formula (II): Also provided are pharmaceutical compositions comprising a compound of Formula (I) or (II) and methods of using such compounds for treating proliferative diseases.
