The present invention relates to a pharmaceutical solution comprisingisotretinoin orpharmaceutically acceptable salts thereof; one or more pharmaceuticallyacceptable excipientsselected from the group consisting of one or more of antioxidants, chelatingagents,preservatives, colors, sweeteners, flavors and mixtures thereof; and apharmaceuticallyacceptable carrier selected from the group consisting of a polyol ester ofmedium chain fatty acidselected from the group consisting of esters and mixed esters of glycerol,propylene glycol,polyglycerol and polyethylene glycol with medium chain fatty acids or mixturesthereof.