Narendra R. Vyavahare;Dan T. Simionescu;Jason C. Isenburg
发明人:
Narendra R. Vyavahare,Jason C. Isenburg,Dan T. Simionescu
申请号：
US12748849
公开号：
US08100961B2
申请日:
2010.03.29
申请国别(地区):
US
年份:
2012
代理人:
摘要：
A method and product are provided for the treatment of connective tissue weakened due to destruction of tissue architecture, and in particular due to elastin degradation. The treatment agents employ certain unique properties of phenolic compounds to develop a protocol for reducing elastin degradation, such as that occurring during aneurysm formation in vasculature. According to the invention, elastin can be stabilized in vivo and destruction of connective tissue, such as that leading to life-threatening aneurysms in vasculature, can be tempered or halted all together. The treatment agents can be delivered or administered acutely or chronically according to various delivery methods, including sustained release methods incorporating perivascular or endovascular patches, use of microsphere carriers, hydrogels, or osmotic pumps.
