Bart DE STROOPER,Patrik VERSTREKEN,Vanessa MORAIS EPIFÂNIO
申请号：
US14440746
公开号：
US20150299672A1
申请日:
2013.11.07
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present application relates to the field of Parkinsons disease (PD), particularly sporadic PD or PD associated with mutations in the mitochondrial kinase PINK1. A new substrate for this kinase, NdufA10, is identified herein. In Parkinsons disease, this protein is dephosphorylated, which is linked to a loss of mitochondrial membrane potential. It is shown that restoring or mimicking phosphorylation of NdufA10 restores the phenotypic defects associated with Parkinsons disease and is thus a new therapeutic paradigm.
