METHODS FOR PROTEIN PRODUCTION EMPLOYING EXPRESSION ENHANCER SEQUENCES DERIVED FROM THE RNA-Z SEGMENT OF A COMOVIRIDAE BIPARTITE RNA VIRUS

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专利权人:

PLANT BIOSCIENCE LIMITED

发明人:

LOMONOSSOFF, GEORGE PETER,SAINSBURY, FRANK

申请号：

CA2711895

公开号：

CA2711895C

申请日:

2009.01.08

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The inventions is based on an expression enhancer sequence derived from theRNA-2 genome segment of a bipartiteRNA virus, in which a target initiation site in the RNA-2 genome segment hasbeen mutated. Deletion of appropriate start codonsupstream of the main RNA2 translation initiation can greatly increase inforeign protein accumulation without the need for viralreplication. Also provided are methods, vectors and systems, including thehyper-translatable Cowpea Mosaic Virus (CPMV-HT)based protein expression system.

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