A multi-fluid injector system and methods of operation thereof are presented. One embodiment of such a fluid injector system includes a powered injector, a pressure jacket support, a syringe pressure jacket, and a syringe. The pressure jacket support includes a front plate and a rear plate. The rear plate is connected to the injector and the front plate is spaced from the rear plate and defines a slot. The syringe pressure jacket has a proximal end pivotally connected to the rear plate so that a distal end of the pressure jacket pivots relative to the front plate. The syringe has a syringe body with a distally extending discharge conduit. With the syringe disposed in a barrel of the pressure jacket, pivotal movement of the pressure jacket results in the distal end thereof pivoting toward the front plate to place the discharge conduit within the slot in the front plate.
