CLARK, Robin,HYND, George,RAY, Nicholas,SAJAD, Mohammad
申请号：
ES12760812
公开号：
ES2563444T3
申请日:
2012.03.16
申请国别(地区):
ES
年份:
2016
代理人:
摘要：
A compound of formula I: ** Formula ** in which the broken line is absent or is a bond； X is selected from the group consisting of O and S； R1 is selected from the group consisting of cycloalkyl, heterocycloalkyl, aryl and heteroaryl, optionally substituted with 1 to 3 R1a groups； each R1a is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6-OR1b alkyl, halogen, C1-6 haloalkyl, C1 haloloxy -6, -OR1b, - NR1bR1c, -C (O) R1b, -C (O) OR1b, -OC (O) R1b, -C (O) NR1bR1c, -NR1bC (O) R1c, -SO2R1b, -SO2NR1bR1c, cycloalkyl, heterocycloalkyl, aryl and heteroaryl； each of R1b and R1c is independently selected from the group consisting of H and C1-6 alkyl； R2 is selected from the group consisting of H, C1-6 alkyl, C1-6-OR1b alkyl, C1-6-NR1bR1c alkyl and C1-6-heterocycloalkyl alkyl； R3 is selected from the group consisting of H and C1-6 alkyl； Ar is aryl, optionally substituted with 1-4 R4 groups； each R4 is independently selected from the group consisting of H, C1-6 alkyl, C1-6 alkoxy, halogen, C1-6 haloalkyl and C1-6 haloalkoxy； L1 is a C1-5 bond or alkylene； The subscript n is an integer from 0 to 3, and salts and isomers thereof.Un compuesto de fórmula I:**Fórmula** en la que la línea discontinua está ausente o es un enlace； X se selecciona de entre el grupo que consiste en O y S； R1 se selecciona de entre el grupo que consiste en cicloalquilo, heterocicloalquilo, arilo y heteroarilo, opcionalmente sustituidos con 1 a 3 grupos R1a； cada R1a se selecciona independientemente de entre el grupo que consiste en H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, alquil C1-6-OR1b, halógeno, haloalquilo C1-6, haloaloxi C1-6, -OR1b, - NR1bR1c, -C(O)R1b, -C(O)OR1b, -OC(O)R1b, -C(O)NR1bR1c, -NR1bC(O)R1c, -SO2R1b, -SO2NR1bR1c, cicloalquilo, heterocicloalquilo, arilo y heteroarilo； cada uno de R1b y R1c se selecciona independientemente entre el grupo que consiste en H y alquilo C1-6； R2 se selecciona de entre el grup
