Provided is an in vivo implantation device configured from a first material and a second material, wherein the antimicrobial in vivo implantation device is characterized in that: at least the surface of the first material contains an antimicrobial metal； at least the surface of the second material is nobler than the first material； an electrical circuit is formed between the first material and the second material when used and implanted in vivo； and ions of the antimicrobial metal are eluted from the first material in the presence of an electrolyte, rendering the surface and/or vicinity of the first material antimicrobial.
