PROBLEM TO BE SOLVED: To obtain a means to eliminate the potential of generating an immune response to a specific therapeutic protein which may have a different amino acid sequence from a host.SOLUTION: The modified therapeutic antibody comprises a therapeutic antibody comprising an antibody combining site which combines with a therapeutic target, wherein the antibody comprises being reversibly modified by a peptide which is a mimotope of a therapeutic target, and the peptide reversibly combines with the antibody combining site of the antibody.COPYRIGHT: (C)2009,JPO&INPIT【課題】宿主と異なるアミノ酸配列を有する可能性がある特定の治療用タンパク質に対する免疫応答を生ずる可能性を排除する手段を得ること。【解決手段】治療標的に結合する抗体結合部位(antibody combining site )を含む治療用抗体を含んでなる修飾型治療用抗体であって、前記抗体が治療標的のミモトープであるペプチドで可逆的に修飾されてなり、前記ペプチドが抗体の抗体結合部位に可逆的に結合する、修飾型治療用抗体。【選択図】なし
