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BIOLOGICALLY ORGANIZABLE OR BIOLOGICALLY DESTRUCTIVE MICROSPHERES OR LONG-TERM RELEASE MICROPARTICLES SUSPENDED IN A CURING DEPOSITIVE INJECTIVE CREAM
专利权人:
ИНК. (US);АЛЛЕРГАН
发明人:
МАРШ Дэвид А. (US),РИВЕРЗ Хонгвен Ма (US)
申请号:
RU2014134420
公开号:
RU2014134420A
申请日:
2013.01.22
申请国别(地区):
RU
年份:
2016
代理人:
摘要:
1. A composite material for drug delivery, comprising: a plurality of microparticles dispersed in a medium, the microparticles comprising: a drug; and a coating containing biodegradable material or biodegradable material; where the composition of the medium contains a drug dispersed in the depot forming material; and where the composition of the medium is in liquid form before administration and is configured to significantly increase the viscosity during or after injection into the mammal so that the form of the medium after injection is solid or gel. 2. A method for treating an ocular disease or injury, comprising injecting a composite material for delivering a medicament according to claim 1 into the eye of a mammal, if necessary. A method according to claim 2, characterized in that a single injection of the composite material of the drug provides a therapeutically effective amount of the drug from about 3 months to about 12 months. The method according to any one of paragraphs. 2-3, characterized in that the ocular disease is macular degeneration or diabetic retinopathy. 5. A composite drug delivery material according to claim 1 or a method according to claim 2, characterized in that the composite drug delivery material is configured to deliver an effective amount of the drug to the injection site for a longer period of time than the composition containing the material environment, and the same amount of drug1. Композитный материал для доставки лекарственного средства, содержащий:множество микрочастиц, диспергированных в составе среды;причем микрочастицы содержат:лекарственное средство; ипокрытие, содержащее биологически разрушаемый материал или биологически разлагаемый материал; игде состав среды содержит лекарственное средство, диспергированное в депообразующем материале;и где состав среды находится в жидкой форме перед введением и сконфигурирован с возможностью значительного увеличения вязкости в течение или после инъецирования в организм млекопитающего для т
来源网站:
中国工程科技知识中心
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