BELMARES, MICHAEL P.,GARMAN, JONATHAN DAVID,LU, PETER S.,SALTER, MICHAEL W.,TYMIANSKI, MICHAEL
申请号：
CA2679831
公开号：
CA2679831C
申请日:
2008.02.29
申请国别(地区):
CA
年份:
2018
代理人:
摘要：
The invention provides methods for treating stroke and compositions for use in the same. The methods employ a chimeric peptide pf an active peptide and an internalization peptide. The internalization peptide is a tat variant that promotes uptake of itself and a linked active peptide into a cell without substantial binding to N-type calcium channels. Use of the tat variant allows treating of stroke free of certain side effects associated with binding to N-type calcium channels. Tat variant peptides can also be linked to other active agent for use in treating other diseases.
