Stephen G. Hoge,William Joseph Issa,Edward John Miracco,Jennifer Nelson,John Reynders,Matthew Stanton
申请号：
US15656740
公开号：
US10072057B2
申请日:
2017.07.21
申请国别(地区):
US
年份:
2018
代理人:
摘要：
The present disclosure provides alternative nucleosides, nucleotides, and nucleic acids, and methods of using them. In some aspects, the disclosure provides mRNA wherein the uracil content has been modified and which may be particularly effective for use in therapeutic compositions, because they may benefit from both high expression levels and limited induction of the innate immune response. In some aspects, the disclosure provides methods for the production of pharmaceutical compositions including mRNA without reverse phase chromatography.
