An apparatus for sensing a physiological signal comprises: two sensing units for respectively connecting to palms of a human being to receive a first electrocardiogram (ECG) signal; a filter unit for generating a second ECG signal by filtering the first ECG signal; an amplifying unit for generating a third ECG signal by amplifying the second ECG signal; an Analog-to-Digital converting unit for converting the third ECG signal into a digital signal; an operating unit for generating a plurality of analysis data by operational analyzing the digital signal; and a monitor unit for displaying the plurality of analysis data. Therefore, the accuracy of the ECG is improved and the operation is simplified.一種生理訊號感測裝置,係包含有:二感測單元,係分別與一待測者之雙手掌連接,以接收一第一心電訊號;一濾波單元,係將該第一心電訊號濾波後產生一第二心電訊號;一放大單元,係將該第二心電訊號放大後產生一第三心電訊號;一類比數位轉換單元,係將該第三心電訊號轉換成一數位訊號;一運算處理單元,係將該數位訊號經過一連串的運算處理後產生複數分析數據資料;以及一顯示單元,用以顯示該各分析數據資料。藉此,可使本發明達到提高心電圖記錄之準確性且操作簡便之功效者。