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DERIVADOS DE CARBOXAMIDAS N-AZABICICLICAS Y SU PREPARACION
- 专利权人:
- SANOFI-AVENTIS
- 发明人:
- DUBOIS, LAURENT,EVANNO, YANNICK,MALANDA, ANDRE,LECLERC, ODILE
- 申请号：
- PE0022972012
- 公开号：
- PE02302013A1
- 申请日:
- 2009.01.20
- 申请国别(地区):
- PE
- 年份:
- 2013
- 代理人:
- 摘要：
- Refers to a compound selected among: N - (2,3 - dimetilimidazo [1,2-a] pirid - 7 - il) - 5 - fluoro - [1 - (3-fluorophenyl) methyl] - 1H indole - 3 - carboxamide n - [2 - (hydroxymethyl) imidazo [1,2-a] pirid IL - 6 - 5 - fluoro -] - [1 - (3-fluorophenyl) methyl] - 1H indole - 3 - carboxamide n - (3 - methyl - 2 - fenilimidazo [1,2-a] pirid - 6 - 5 - fluoro - il) - [1 - (3-fluorophenyl) methyl] - 1H indole - 3 - carboxamide n - [2 - (tert butilimidazo 12 -] pirid - il) - 6 - 5 - fluoro - [1 - (3-fluorophenyl) methyl] - 1H indole - 3 - carboxamide n - (2 - metoximetilimidazo [1,2-a] pirid - 7 - il) - 5 - fluoro - [1 - (3-fluorophenyl) methyl] - 1H indole - 3 - carboxamide n - [2 - (- 2 - il) imidazo [1,2-a] pirid - 7 - yl] - 5 - fluoro - [1 - (3-fluorophenyl) methyl] - 1H indole - 3 - carboxamide among others. Also referred to as a preparation method and a Pharmaceutical composition.These compounds are useful as modulators of the TRPV1 receptor for the treatment of Asthma, colitis, Cough, herpes esophagitisSE REFIERE A UN COMPUESTO SELECCIONADO ENTRE: N-(2,3-DIMETILIMIDAZO[1,2-a]PIRID-7-IL)-5-FLUORO-1-[(3-FLUOROFENIL)METIL]-1H-INDOL-2-CARBOXAMIDA N-[2-(HIDROXIMETIL)IMIDAZO[1,2-a]PIRID-6-IL]-5-FLUORO-1-[(3-FLUOROFENIL)METIL]-1H-INDOL-2-CARBOXAMIDA N-(3-METIL-2-FENILIMIDAZO[1,2-a]PIRID-6-IL)-5-FLUORO-1-[(3-FLUOROFENIL)METIL]-1H-INDOL-2-CARBOXAMIDA N-(2-TERC-BUTILIMIDAZO[1,2-a]PIRID-6-IL)-5-FLUORO-1-[(3-FLUOROFENIL)METIL]-1H-INDOL-2-CARBOXAMIDA N-(2-METOXIMETILIMIDAZO[1,2-a]PIRID-7-IL)-5-FLUORO-1-[(3-FLUOROFENIL)METIL]-1H-INDOL-2-CARBOXAMIDA N-[2-(TIEN-2-IL)IMIDAZO[1,2-a]PIRID-7-IL]-5-FLUORO-1-[(3-FLUOROFENIL)METIL]-1H-INDOL-2-CARBOXAMIDA ENTRE OTROS. REFERIDO ADEMAS A UN PROCEDIMIENTO DE PREPARACION Y A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON MODULADORES DE LOS RECEPTORES TRPV1 SIENDO UTILES PARA EL TRATAMIENTO DEL ASMA, COLITIS, TOS, HERPES, ESOFAGITIS
- 来源网站：
- 中国工程科技知识中心
- 来源网址：
- http://www.ckcest.cn/home/
