Nils Ahlgren,Mark Nuttall,Jeannie Wong,Venkatesh Balasubramanian,Craig Belongie,Ashfaq Khan,Neil Campbell Muir
申请号：
US15133062
公开号：
US20160228386A1
申请日:
2016.04.19
申请国别(地区):
US
年份:
2016
代理人:
摘要：
A pharmaceutical composition in the form of a tablet including a first portion and a second portion, wherein the first portion includes guaifenesin having an immediate release profile and a second drug having a sustained release profile, and wherein the second portion includes guaifenesin having a sustained release profile. The second drug can be in the form of a drug-resin complex. The second drug can be either an anti-tussive or a decongestant. The drug-resin complex includes a drug complexed to an ion exchange resin. The ion exchange resin can be a polystyrene sulfonate resin, polacrilex resin, polacrilin potassium, cholestyramine resin, or a colestyramine resin. The drug-resin complex can be provided with a coating, the coating thickness being selected to obtain the desired release profile. The drug-resin complex can be provided with a coating level of from 5% to 50%. The coating level can be from 10% to 35%.
