Gregory Paul Dittmar;Tony Ryan Cronk;Daniel Gary Newby;Joseph Michael Amante
发明人:
Gregory Paul Dittmar,Joseph Michael Amante,Tony Ryan Cronk,Daniel Gary Newby
申请号：
US11070995
公开号：
US08580302B2
申请日:
2005.03.03
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The present invention relates to a pharmaceutical composition in a solid unit dosage form for oral administration in a human or lower animal comprising: a. a safe and effective amount of a therapeutically active agent； b. an inner coating layer selected from the group consisting of poly(methacrylic acid, methyl methacrylate) 1:2, poly(methacrylic acid, methyl methacrylate) 1:1, and mixtures thereof； and c. an outer coating layer comprising an enteric polymer or film coating material； wherein the inner coating layer is not the same as the outer coating layer； wherein if the inner coating layer is poly(methacrylic acid, methyl methacrylate) 1:1 then the outer coating layer is not poly(methacrylic acid, methyl methacrylate) 1:2 or is not a mixture of poly(methacrylic acid, methyl methacrylate) 1:1 and poly(methacrylic acid, methyl methacrylate) 1:2； and wherein the inner coating layer and the outer coating layer do not contain any therapeutically active agent. This invention further relates to a method of maintaining the desired site of delivery of a therapeutic agent in the gastrointestinal tract by administering the above compositions to a human or lower animal.
