CHAN KYLE W H,FUNG LEAH,SULLIVAN ROBERT,ERDMAN PAUL E,MERCURIO FRANK
申请号：
IN201717040878
公开号：
IN201717040878A
申请日:
2017.11.15
申请国别(地区):
IN
年份:
2018
代理人:
摘要：
The present invention provides modulators of protein function to restore protein homeostasis including cytokine aiolos and/or ikaros activity and cell cell adhesion. The invention provides methods of modulating protein mediated diseases such as cytokine mediated diseases disorders conditions or responses. Compositions including in combination with other cytokine and inflammatory mediators are provided. Methods of treatment amelioration or prevention of protein mediated diseases disorders and conditions such as cytokine mediated diseases disorders and conditions including inflammation fibromyalgia rheumatoid arthritis osteoarthritis ankylosing spondylitis psoriasis psoriatic arthritis inflammatory bowel diseases Crohn s disease ulcerative colitis uveitis inflammatory lung diseases chronic obstructive pulmonary disease Alzheimer s disease and cancer are provided.
