Shanghai Hansoh Biomedical Co., Ltd.;Jiangsu Hansoh Pharmaceutical Group Co., Ltd.
发明人:
Mingsong WEI,Guangjun SUN,Songliang TAN,Peng GAO,Shaobao WANG,Wenhua XIU,Fujun ZHANG,Rudi BAO
申请号：
US16207968
公开号：
US20190100528A1
申请日:
2018.12.03
申请国别(地区):
US
年份:
2019
代理人:
摘要：
Epidermal growth factor receptor (EGFR) inhibitors are provided. In particular, 4-substituted-2-(N-(5-substituted ally amide)phenyl)amino)pyrimidine derivatives of formula (I), a preparation method and use thereof as an EGFR inhibitor are provided. The 4-substituted-2-(N-(5-substituted ally amide)phenyl)amino)pyrimidine derivatives of formula (I) have inhibitory activity against the L858R EGFR mutant, the T790M EGFR mutant and the exon 19 deletion activating mutant, and can be used to treat diseases mediated alone or in part by EGFR mutant activity. The derivatives of formula (I) can be used to treat and/or prevent cancers, particularly non-small cell lung cancer.
