Andrew BUCHANAN,Matthieu CHODORGE,Peter CARIUK,Johanna HUSMARK,Clare BALENDRAN,Deepesh PANDEY,Fumin CHANG,Daniel E. BERKOWITZ,Lewis H. ROMER
申请号：
US15516115
公开号：
US20170304343A1
申请日:
2015.09.30
申请国别(地区):
US
年份:
2017
代理人:
摘要：
This disclosure provides LOX1 (LOX1) binding proteins such as anti-LOX1 antibodies, and compositions and methods for making these binding proteins. In certain aspects the LOX1-binding proteins provided herein, inhibit, or antagonize LOX1 activity. In addition, the disclosure provides compositions and methods for diagnosing and treating conditions associated with atherosclerosis, thrombosis, coronary artery disease (CAD), ischemia (e.g., myocardial ischemia), infarction (e.g., myocardial infarction), acute coronary syndrome (ACS), stroke, reperfusion injury, restenosis, peripheral vascular disease, hypertension, heart failure, inflammation (e.g., chronic inflammation), angiogenesis, preeclampsia, cancer and other LOX1-mediated diseases and conditions.
