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INTERMITTENT DOSING OF MDM2 INHIBITOR
专利权人:
发明人:
Stephane FERRETTI,Sebastien JEAY
申请号:
US15849770
公开号:
US20180110779A1
申请日:
2017.12.21
申请国别(地区):
US
年份:
2018
代理人:
摘要:
The present disclosure relates to mdm2 inhibitors for use in specific dosing schedules. It was found that if sufficiently potent or, in alternative, sufficiently high dose of a Mdm2 inhibitor is used, it can cause antineoplastic effect by triggering much longer lasting antiproliferative mechanism in cells. The long lasting effect can sustain for several weeks after a single dose, which eliminates the need for daily treatment and allows administering the Mdm2i intermittently. A treatment with the intermittent dosing schedule of a Mdm2 inhibitor can be combined with a daily treatment of the Mdm2i or with another pharmaceutically acceptable ingredient.
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