Methods and medicaments for preventing or treating neuropsychiatric disorderand/or a neurological disorder including a neurological disorder mediated bythe thalamus. Neuropsychiatric disorders and/or a neurological disorders,including a thalamically mediated disorder can be treated by peripheraladministration of a medicament containing a botulinum toxin to or to thevicinity of a trigeminal sensory nerve, thereby preventing or treating aneurological disorder and/or a neuropsychiatric disorder.
