BRETT ADAM BOGHIGIAN,DAVID ARTHUR BERRY,GEOFFREY VON MALTZAHN,MICAHEL J. HAMILL,NATHANIEL W. SILVER,RAJEEV CHILLAKURU
申请号:
BR112014023792
公开号:
BR112014023792A2
申请日:
2013.03.15
申请国别(地区):
BR
年份:
2017
代理人:
摘要:
Abstract nutritive proteins are provided. in some embodiments the nutritive proteins comprising a first polypeptide sequence comprising a fragment of a naturally-occurring nutritive protein. in some embodiments the fragment comprises at least one of a) an enhanced ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) an enhanced ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) an enhanced ratio of essential amino acid residues to total amino acid residues present in the nutritive protein. in some embodiments, the fragment comprises at least one of a) the ratio of branch chain amino acid residues to total amino acid residues present in the nutritive protein; b) the ratio of leucine residues to total amino acid residues present in the nutritive protein; and c) the ratio of essential amino acid residues to total amino acid residues present in the nutritive protein, which is equal to or greater than the corresponding ratio present in a benchmark protein such as whey, egg or soy protein. also provided are nucleic acids encoding the proteins, recombinant microorganisms that make the proteins, methods of making the proteins using recombinant microorganisms, compositions that comprise the proteins, and methods of using the proteins, among other things. -------------------------------------------------- -------------------------------------------------- ----- translation of abstract summary "loaded nutritive proteins and methods". Nutritional proteins are provided. In some embodiments the nutritive proteins comprise a first polypeptide sequence comprising a fragment of a naturally occurring nutritive protein. in some embodiments the fragment comprises at least one of a) an enhanced ratio of branched chain amino acid residues to total amino acid residues present in the nutritive protein; b) an increased ratio of leucine residues to total amino acid residues present in the nutr