A robot system for oral cavity and tooth treatment. The system includes a console, a seat device, a robot and a navigation device. The console includes a display device, an operating device and an emergency stop device. The seat device includes a body support portion, an orientation adjustment portion and a head fixing portion. The robot comprises a main controller, a robotic arm, a manipulator. The navigation device performs navigation inside a tooth in a root canal treatment operation according to pre-stored tooth information. The treatment instrument in the manipulator can be replaceable. The seat device can be adjusted such that a patient can face any direction between forward and downward, or lie prostrate.