PROBLEM TO BE SOLVED: To provide a composition for prevention and/or therapy of fibrous disorders.SOLUTION: A composition comprises a benzo [c] chromene-6-one derivative represented by SG00529 or the like as an active ingredient, and is useful for prevention and/or therapy for fibrous disorders such as pulmonary fibrosis, systemic sclerosis, scleroderma, proliferative vitreoretinopathy, hepatic cirrhosis, pancreas and pulmonary cystic fibrosis, endomyocardial fibrosis, pulmonary idiopathic pulmonary fibrosis, mediastinal fibrosis, myelofibrosis, retroperitoneal fibrosis, nephrogenic systemic fibrosis, progressive massive fibrosis, injection fibrosis, glomerulonephritis, diabetic nephropathy, malignant nephrosclerosis, thrombotic microangiopathy syndrome, graft rejection, glomerulopathy, diffuse parenchymal pulmonary disease, post-vasectomy pain syndrome, tuberculosis, splenic fibrosis caused by sickle cell anemia, and rheumatoid arthritis.【課題】線維性障害を予防及び／又は治療するための組成物の提供。【解決手段】下記ＳＧ００５２９等で例示されるベンゾ［ｃ］クロメン－６－オン誘導体を有効成分として含み、肺線維症、全身性硬化症、強皮症、増殖性硝子体網膜症、肝硬変、膵臓及び肺の嚢胞性線維症、心内膜心筋線維症、肺の特発性肺線維症、縦隔線維症、骨髄線維症、後腹膜線維症、腎性全身性線維症、進行性塊状線維症、注射線維症、糸球体腎炎、糖尿病性腎症、悪性腎硬化症、血栓性微小血管症候群、移植片拒絶、糸球体症、びまん性実質性肺疾患、精管切除後疼痛症候群、結核、鎌状赤血球貧血により引き起こされる脾臓線維症、関節リウマチ等の線維性障害の予防及び／又は治療に有用な組成物。【選択図】なし
