The present invention additionally provides a kit for collecting the sinonasal specimen to analyze which pathogenic microbes cause a disease in a mammal, how to test the drug sensitivity against the infectious microbes in sinonasal cavities, and to help the selection of a pharmaceutical composition to selectively treat a disease of a mammal. The present invention also provides a pharmaceutical composition comprising a chemical compound or a herb extract or the combination having at least one of the activities of antiviral, antibacterial, antifungal, anti-inflammatory, anti-allergy, anti-cancer, promoting membrane healing or immunomodulating, for the treatment and prevention of a disease of a mammal. The invented method of treating a human disease reduces infectious and inflammation without causing antibiotic resistance or clinically noticeable adverse event.
