Fused pyrimidinone derivatives as modulators of cystic fibrosis transmembrane conductance regulator

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专利权人:

VERTEX PHARMACEUTICALS INCORPORATED

发明人:

BINCH, HAYLEY,GROOTENHUIS, PETER, D

申请号：

NZ58627108

公开号：

NZ586271A

申请日:

2008.12.12

申请国别(地区):

NZ

年份:

2012

代理人:

摘要：

The disclosure relates to modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof represented by formula (I), including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith, wherein the variables shown in formula (I) are as defined in the specification. These compounds of formula (I) are suitable for modulating CFTR activity and are useful for treating diseases caused by mutation in CFTR.

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