A system for tracking a multi-component, tamper evident closure assembly for a pre-filled syringe along a distribution route, including a predetermined code applied to each of a plurality of components of the same closure assembly and comprising electronically readable coded indicia, is structured to identify and distinguish each of a plurality of closure assemblies from one another. A reading and recording of predetermined code for each closure assembly along the distribution route is accomplished. The location at which tampering of a closure assembly has occurred along the corresponding distribution route can be accomplished by reading the coded indicia segments on any of detached or assembled ones of the plurality of originally assembled components of the same closure assembly.
