THE UNITED STATES OF AMERICA; AS REPRESENTED BY THE SECRETARY; DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人:
KWONG, PETER,GRAHAM, BARNEY,MASCOLA, JOHN,OU, LI,DRUZ, ALIAKSANDR,CHEN, MAN,KONG, WING-PUI,GEORGIEV, IVELIN STEFANOV,RUNDLET, EMILY,JOYCE, MICHAEL GORDON,TSYBOVSKY, YAROSLAV,THOMAS, PAUL,PANCERA, MARI
申请号：
CA3015570
公开号：
CA3015570A1
申请日:
2017.03.29
申请国别(地区):
CA
年份:
2017
代理人:
摘要：
Embodiments of a recombinant Respiratory Syncytial Virus (RSV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also disclosed are nucleic acids encoding the RSV F ectodomain trimer and methods of producing the RSV F ectodomain trimer. Methods for inducing an immune response in a subject are also disclosed. In some embodiments, the method can be a method for treating or preventing a RSV infection in a subject by administering a therapeutically effective amount of the recombinant RSV F ectodomain trimer to the subject.
