Substituted (e)-n&rsquo-(1-phenylethylidene) benzohydrazide analogs as histone demethylase inhibitors

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专利权人:

UNIVERSITY OF UTAH RESEARCH FOUNDATION

发明人:

VANKAYALAPATI HARIPRASAD,SORNA VENKATASWAMY,WARNER STEVE L.,BEARSS DAVID J.,SHARMA SUNIL,STEPHENS BRET

申请号：

NZ62107812

公开号：

NZ621078A

申请日:

2012.08.15

申请国别(地区):

NZ

年份:

2015

代理人:

摘要：

Provided are substituted (E)-N&rsquo-(1-phenylethylidene) benzohydrazide analogue compounds, of the general formula (I), wherein the variables are as defined in the specification. Examples of the compounds include (E)-N&rsquo-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide and (E)-3-(2-(1-(5-chloro-2-hydroxyphenyl)ethylidene)hydrazinecarbonyl)-N-methylbenzenesulfonamide. The compounds are lysine-specific demethylase inhibitors. The compounds may be useful in the treatment of cancer.

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