Elizabeth A. Jaffee,Tzyy-Choou Wu,Chien-Fu Hung,Ralph Hruban
申请号：
US16460993
公开号：
US20200093911A1
申请日:
2019.07.02
申请国别(地区):
US
年份:
2020
代理人:
摘要：
Mesothelin can be used as an immunotherapeutic target. It induces a cytolytic T cell response. Portions of mesothelin which induce such responses are identified. Vaccines can be either polynucleotide- or polypeptide-based. Carriers for raising a cytolytic T cell response include bacteria and viruses. A mouse model for testing vaccines and other anti-tumor therapeutics and prophylactics comprises a strongly mesothelin-expressing, transformed peritoneal cell line.
